Characterization of pathogenetically distinct phenotypes of MS by structural MRI imaging in combination with optical coherence tomography

Principle investigator:   Dr. Sven Schippling

Source: Heidelberg Engineering GmbH

Research focus

Building on a previously described MRI algorithm developed by our group, we will prospectively recruit and stratify patients recently diagnosed with relapsing remitting Multiple Sclerosis (RRMS) based on two consecutive structural MRIs into subgroups that differentially display hallmark features of the disease: inflammation/demyelination, neurodegeneration/atrophy and remyelination/repair. The MRI protocol consists of structural and quantitative MRI sequences (high-resolution gradient echo T1 pre- and post contrast, PD/T2, 3-D fluid attenuated inversion recovery (FLAIR), double inversion recovery (DIR) and diffusion tensor imaging (DTI).

In addition patients will be assessed by optical coherence tomography (OCT) applying two different protocols:

  • Peripapillary ring scan
  • Posterior pole macular volume scans using latest spectral domain (SD)-OCT technology (Heidelberg Spectralis®, Heidelberg Engineering, Heidelberg, Germany).