Autoantigens and disease heterogeneity
Principle investigator: Dr. Mireia Sospedra Ramos
Our research aims are:
- The identification of the antigen specificity and functional phenotype of autoreactive CD8+ T cells that are clonally expanded in the brains of MS patients with distinct phenotypes, e.g. 'Lucchinetti/Brück/Lassmann type 2' disease, which is characterized by T cell infiltration, antibody- and complement deposition
- Addressing in a larger number of patients if the antigens identified under aim above are related to specific MS phenotypes.